Pharmaceutical-Grade For Laboratory Animal Research
Heparinized glycerol and heparinized glucose are commonly used catheter lock solutions in laboratory animal research thanks in part to their performance in the “Comparison of Catheter Lock Solutions in Rats” paper by Dr. Luo et al in 2000.
When working with these viscous compounds with relatively high concentrations of heparin, you must be mindful of the catheter dead volume and careful not to inject any into the animal.
These solutions are prepared with heparin sodium following the USP standard for compounding sterile preparations. They are available in 10ml and 50ml vials, optionally with Instech’s needlefree PinPort™ technology built into the caps, as well as prefilled syringes. If you are working with Instech Vascular Access Buttons™ or PinPorts™ you will be able draw up solutions from these vials using a PNP3M injector.
The 50ml vials are sold individually; the 10ml vials in packs of five. In general multi-dose vials should be used within 28 days of the first access. Syringes come in 50 piece packs (10 packs of five).
While high heparin concentration solutions are mostly needed with open systems, they may not be necessary when using a closed system as provided by the Vascular Access Button™. As an alternative, many people relying on a closed system successfully use heparinized saline to lock their catheters, especially in the venous system. These solutions are also prepared with heparin sodium following the USP standard for compounding sterile preparations. This formulation is available in the form of sterile easy to use prefilled sterile syringes.
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These solutions are not approved for human use. They are for laboratory animal research only. AAALAC recommends that pharmaceutical-grade compounds be used in laboratory animal research when available.
